Recently, Professor Dai Honglian's research group from the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing of WUT made remarkable progress in the field of peripheral nerve repair, and developed an injectable and adaptable hydrogen sulfide delivery system that efficiently repairs damaged peripheral nerves. They also elucidated, for the first time, the regulatory mechanism of H2S on the microenvironment of peripheral nerve injuries. The research results were published in Science Advances, a sub-journal of Science, titled "An Injectable and Adaptable Hydrogen Sulfide Delivery System for Modulating Neuroregenerative Microenvironment."

Figure 1: Schematic illustration of constructing H2S responsive nerve grafts using reactive oxygen species (ROS) for peripheral nerve injury (PNI) repair.

Figure 2: H2S regulating microenvironmental nerve regeneration

The first author of the paper is Dr. Dong Xianzhen from Wuhan University of Technology, with Dr. Zhang Hao from Zhongnan Hospital of Wuhan University as the co-first author. The corresponding authors are Professor Dai Honglian from Wuhan University of Technology, Professor Yu Aixi from Zhongnan Hospital of Wuhan University, and Professor Yan Lesan from Wuhan University of Technology.

Article link: Dong X, Zhang H, Duan P, et al. An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment. Science Advances, 2023, 9 (51): eadi1078.

[https://www.science.org/doi/10.1126/sciadv.adi1078] 

Professor Dai Honglian's team has long been engaged in the research and development of biomedical materials and medical devices, including tissue repair and regeneration materials, nano-bio composite materials, injectable biomaterials, magnetic biomaterials, and drug release materials. They have conducted extensive research in areas such as biomimetic design and preparation of materials, surface modification of materials, 3D bioprinting, and the biological effects of materials. The research results have been published in high-impact academic journals such as Science Advances, Advanced Functional Materials, and Biomaterials, and multiple national invention patents have been granted.

Reported by: Huang Linglin

Rewritten by: Zou Yingqi

Edited by: Yu Mengmei, Li Tiantian

Source: State Key Laboratory of Advanced Technology For Materials Synthesis and Processing